7β-hydroxysteroid dehydratase Hsh3 eliminates the 7-hydroxy group of the bile salt ursodeoxycholate during degradation by Sphingobium sp. strain Chol11 and other Sphingomonadaceae
Phil Richtsmeier, Ruslan Nedielkov, Malte Haring, Onur Yücel, Lea Elsner, Rebekka H. Lülf, Lars Wöhlbrand, Ralf Rabus, Heiko M. Moeller, Bodo Philipp, Franziska Maria Mueller
This paper identifies Hsh3, an enzyme in Sphingobium sp. strain Chol11 that degrades ursodeoxycholate by removing its 7β-hydroxy group, and shows its role in bile salt degradation and potential biotechnological applications.
Applied and Environmental Microbiology · May 9, 2025Peer-reviewedMicrobiology