Microbiota-derived indole-3-propionic acid regulates glucose homeostasis via remodeling of hepatic mitochondrial metabolism
Or Maalumi, Ziv Ben Moshe, Or Blank, Rachel Barkan-Michaeli, Avihu H. Yona, Kfir Sharabi
This study identifies indole-3-propionic acid (IPA), a microbial metabolite, as a regulator of hepatic glucose metabolism by remodeling mitochondrial function and improving glucose homeostasis in mice.
bioRxiv · May 13, 2026 · PreprintPhysiology