Molecular determinants of differential substrate selection between the Src family kinases Lck and Src
KONSTANTINA KARPOUZOU, Marco D’Abramo, Alessandro Grottesi, Oreste Acuto, Konstantina Nika
The paper investigates how Lck and Src kinases differ in their ability to phosphorylate ITAMs, identifying structural and conformational differences that underlie their substrate specificity.
Frontiers in Immunology · Aug 10, 2026Peer-reviewedCell Biology