Author

Alessandro Grottesi

CinecaORCID 0000-0002-2168-5075Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Alessandro PaiardiniiD· 1 shared Gabriele AusielloiD· 1 shared Giacomo JansoniD· 1 shared Giulia GuarguagliniiD· 1 shared KONSTANTINA KARPOUZOU· 1 shared Konstantina NikaiD· 1 shared Marco D’AbramoiD· 1 shared Marco PietrosantoiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 16 mutual co-author links

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1 shared paperBioinformatics

Alessandro PaiardiniORCID

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2 papers

Recent·Most cited

Molecular determinants of differential substrate selection between the Src family kinases Lck and Src

KONSTANTINA KARPOUZOU, Marco D’Abramo, Alessandro Grottesi, Oreste Acuto, Konstantina Nika

The paper investigates how Lck and Src kinases differ in their ability to phosphorylate ITAMs, identifying structural and conformational differences that underlie their substrate specificity.

Frontiers in Immunology · Aug 10, 2026Peer-reviewedCell Biology

Revisiting the \"satisfaction of spatial restraints\" approach of MODELLER for protein homology modeling

Giacomo Janson, Alessandro Grottesi, Marco Pietrosanto, Gabriele Ausiello, Giulia Guarguaglini, Alessandro Paiardini

This paper improves MODELLER's 3D protein modeling by modifying its estimation of structural divergence and incorporating statistical potentials, enhancing prediction accuracy.

PLoS Computational Biology · Dec 17, 2019Peer-reviewedBioinformatics