Piezo ion channel activation increases the release of therapeutic extracellular vesicles after mechanical stimulation in bioreactors
André Cronemberger Andrade, Oriane Le Goas, Shony Lemieux, Alice Grangier, Alice Nicolai, Ida Chiara Guerrera, Christopher Ribes, Estelle Suply, Jeanne Volatron, Florence Gazeau, Amanda Silva
This study shows that activating Piezo1 ion channels via mechanical shear stress increases extracellular vesicle production from adipose-derived stromal cells in bioreactors.
bioRxiv · Jan 9, 2025 · PreprintCell Biology