Binding of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition
Jamal Fahoum, Maria Billan, Julia K. Varga, Dan Padawer, Elena Britan‐Rosich, Maya Elgrably‐Weiss, Pallabi Basu, Miri Stolovich-Rain, Leah Baraz, Einav Cohen‐Kfir, Sujata Kumari, Esther Oiknine‐Djian, Manoj Kumar, Orly Zelig, Guy Mayer, , Alexander Rouvinski
This study shows that SARS-CoV-2 nucleocapsid protein binds to uninfected cells, triggering antibody-mediated complement activation in COVID-19 patients.
Cell Reports · May 1, 2025Peer-reviewedImmunology