Topoisomerase IIβ targets DNA crossovers formed between distant homologous sites to modulate chromatin structure and gene expression
Mary Miyaji, Ryohei Furuta, Osamu Hosoya, Kuniaki Sano, Norikazu Hara, Ryozo Kuwano, Jiyoung Kang, Masaru Tateno, Kimiko Tsutsui, Ken Tsutsui
The paper identifies two modes of topoisomerase IIβ action, showing it resolves distant DNA crossovers to regulate chromatin structure and gene expression during neuronal differentiation.
bioRxiv · Oct 18, 2019 · PreprintMolecular Biology