Ryozo Kuwano

Association of rare APOE missense variants with Alzheimer's disease in the Japanese population

The paper identifies APOE rare missense variants in the Japanese population and finds two variants associated with protective effects against Alzheimer's disease.

Polygenic effects on the risk of Alzheimer's disease in the Japanese population

This paper evaluates the polygenic risk score for Alzheimer's disease in Japanese individuals, showing its utility despite genetic differences from European populations.

Disruption of a RAC1-centred protein interaction network is associated with Alzheimer’s disease pathology and causes age-dependent neurodegeneration

The paper identifies RAC1 as a key gene in Alzheimer's disease progression through a protein domain network analysis and validates its role using Drosophila models and miRNA regulation.

Topoisomerase IIβ targets DNA crossovers formed between distant homologous sites to modulate chromatin structure and gene expression

The paper identifies two modes of topoisomerase IIβ action, showing it resolves distant DNA crossovers to regulate chromatin structure and gene expression during neuronal differentiation.

Enhancer variants associated with Alzheimer’s disease affect gene expression via chromatin looping

The paper identifies enhancer variants linked to Alzheimer's disease that influence gene expression through chromatin looping mechanisms.