BiophysicsbioRxivPreprint
In-Solution Measurements of Binding Kinetics and Thermodynamics by nano Temperature Alteration Kinetics
Andreas Langer, Christian Osseforth, Philipp Schramm…·Oscar Reinecke
This paper introduces nanoTAK, a method to measure fast binding kinetics and thermodynamics using spectral shifts, validated across DNA, protein-ligand, and PROTAC systems.
DOI 10.64898/2026.10.22.760345