Intravenously Delivered Lipid Nanoparticles Access Acute Spinal Cord Injury via Disrupted Vasculature
Jacobus Burger, Luke J. Bolstad, Mia J. LaRico, Owen R. Lefebvre, Roy Ram Klein, Asma Eslami, William L. Murphy, Amgad Hanna, Daniel J. Hellenbrand
This study shows that intravenously delivered mRNA-lipid nanoparticles can access the injured spinal cord via disrupted blood-spinal cord barrier, achieving local transgene expression in multiple cell types.
bioRxiv · Jun 9, 2026 · PreprintNeuroscience