P. A. Goloubinoff

In vitro evolution of uracil glycosylase towards DnaKJ and GroEL binding evolves different misfolded states

This study uses in vitro evolution to select uracil glycosylase mutants binding to GroEL, DnaKJ, or E. coli extract, revealing distinct misfolded states and selection pressures.

On the evolution of chaperones and co-chaperones and the expansion of proteomes across the Tree of Life

The paper analyzes proteome complexity across the Tree of Life, showing significant expansion in protein numbers, size, and fold diversity, accompanied by the evolution of chaperone systems to manage protein quality.