G. Schreiber

Specificity and promiscuity of JAK recruitment regulates pleiotropy of cytokine-receptor signaling

The paper investigates JAK recruitment specificity and promiscuity in cytokine-receptor signaling, finding that JAKs can interchangeably bind to receptors, leading to cell type-specific signaling pleiotropy.

RBD-based high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways

RBD-62, a high-affinity ACE2 antagonist, limits SARS-CoV-2 replication in both upper and lower airways in rhesus macaques without blocking memory responses or causing anti-drug immunity.

Reversing protonation of weakly basic drugs greatly enhances intracellular diffusion and decreases lysosomal sequestration

Enhanced transmissibility, infectivity and immune resistance of the SARS-CoV-2 Omicron XBB.1.5 variant

This study evaluates the transmissibility, infectivity, and immune resistance of the SARS-CoV-2 Omicron XBB.1.5 variant, finding it more transmissible and resistant than previous variants.

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

This study identifies XBB as a SARS-CoV-2 variant resulting from recombination of BA.2 subvariants, showing increased resistance to neutralizing antibodies and enhanced fusogenicity compared to BA.2.75.

Convergent evolution of the SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

The paper investigates convergent evolution in SARS-CoV-2 Omicron subvariants, identifying five critical spike protein substitutions in BQ.1.1 that enhance viral fitness and antibody resistance.

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques

This study shows that modulating type I interferon responses in rhesus macaques reduces SARS-CoV-2 viral load and inflammation, suggesting a potential therapeutic strategy for severe COVID-19.

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75

This study investigates the virological characteristics of SARS-CoV-2 Omicron BA.2.75, finding it has higher transmissibility and pathogenicity compared to BA.2 and BA.5, but similar sensitivity to antiviral drugs.

Virological characteristics of the novel SARS-CoV-2 Omicron variants including BA.2.12.1, BA.4 and BA.5

This study analyzes the virological characteristics of SARS-CoV-2 Omicron variants BA.2.12.1, BA.4, and BA.5, finding they have higher reproduction numbers, reduced neutralization by prior immunity, increased replication in lung cells, and greater pathogenicity in hamsters compared to BA.2.

SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant

This study identifies the S375F mutation in the Omicron spike protein as responsible for its reduced cleavage efficiency, fusogenicity, and rapid spread.

Protein Quaternary Structures in Solution are a Mixture of Multiple forms

The paper assesses the oligomeric states of 17 bacterial proteins using multiple techniques, finding that most exist in multiple forms and that AlphaFold Multimer better predicts their quaternary structures than existing databases.

Genetically engineered MRI-trackable extracellular vesicles as SARS-CoV-2 mimetics for mapping ACE2 binding in vivo

This paper develops MRI-trackable extracellular vesicles displaying SARS-CoV-2 RBD to map ACE2 binding in vivo and screen viral variants.

Virological characteristics of SARS-CoV-2 BA.2 variant

This study compares the virological characteristics of SARS-CoV-2 BA.2 and BA.1 variants, finding BA.2 has higher transmissibility, different antigenicity, greater replicative capacity, and higher pathogenicity in hamsters.

Diffusion of small molecule drugs is affected by surface interactions and crowder proteins

This study examines how protein crowders affect the diffusion of small molecules, finding varied impacts based on molecular interactions and self-aggregation.

In vitro evolution of uracil glycosylase towards DnaKJ and GroEL binding evolves different misfolded states

This study uses in vitro evolution to select uracil glycosylase mutants binding to GroEL, DnaKJ, or E. coli extract, revealing distinct misfolded states and selection pressures.

SARS-CoV-2 convergent evolution as a guide to explore adaptive advantage

This paper analyzes convergent evolution in SARS-CoV-2 spike protein mutations to identify adaptive advantages and understudied variants.

An emerging SARS-CoV-2 mutant evading cellular immunity and increasing viral infectivity

This study identifies two SARS-CoV-2 mutations, L452R and Y453F, that evade HLA-restricted cellular immunity and increase viral infectivity.

SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor

The paper shows that in vitro evolved SARS-CoV-2 RBD mutations, like S477N, E484K, and N501Y, correlate with increased infectivity and are inhibited by high-affinity RBD drugs.

An enhanced yeast display platform demonstrates the binding plasticity under various selection pressures

This paper enhances a yeast display platform with improved protein stability and fluorescence, demonstrating binding plasticity under different selection pressures.

Line-FRAP, a versatile method based on fluorescence recovery after photobleaching to measure diffusion rates in vitro and in vivo

Line-FRAP measures diffusion rates in vitro and in vivo using confocal microscopy, showing slower diffusion in cells compared to buffer and osmotic pressure effects.