In Silico Identification and In Vitro Validation of Novel KPC-2 β-lactamase Inhibitors
R. Klein, P. Linciano, G. Celenza, P. Bellio, S. Papaioannou, J. Blazquez, L. Cendron, R. Brenk, D. Tondi
This study identifies and validates novel non-β-lactam inhibitors of KPC-2 β-lactamase through in silico screening and in vitro testing, showing one compound reduces meropenem MIC by fourfold.
bioRxiv · Aug 20, 2018Biochemistry