Author

R. Brenk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:deep learning· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

B. E. Haug· 1 shared C. Sotriffer· 1 shared C. Wiedemann· 1 shared D. Tondi· 1 shared F. Khorsand· 1 shared G. Celenza· 1 shared H. Schindelin· 1 shared I. Kursula· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

B. E. Haug

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Expression and purification of human neutrophil proteinase 3 from insect cells and characterization of ligand binding

F. Khorsand, B. E. Haug, I. Kursula, N. Reuter, R. Brenk

This study expresses and purifies recombinant human neutrophil proteinase 3 (PR3) from insect cells, demonstrating its activity and utility for drug discovery and ligand binding studies.

bioRxiv · Nov 10, 2023Biochemistry

Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97

S. Bothe, P. Haenzelmann, S. Boehler, J. Kehrein, C. Wiedemann, U. Hellmich, R. Brenk, H. Schindelin, C. Sotriffer

The paper uses biolayer interferometry to identify small molecule ligands targeting the SHP-motif binding site of p97, leading to the first structure of a small molecule complex with the N-domain of p97.

bioRxiv · Jun 1, 2022Biochemistry

In Silico Identification and In Vitro Validation of Novel KPC-2 β-lactamase Inhibitors

R. Klein, P. Linciano, G. Celenza, P. Bellio, S. Papaioannou, J. Blazquez, L. Cendron, R. Brenk, D. Tondi

This study identifies and validates novel non-β-lactam inhibitors of KPC-2 β-lactamase through in silico screening and in vitro testing, showing one compound reduces meropenem MIC by fourfold.

bioRxiv · Aug 20, 2018Biochemistry