Validation of novel Mycobacterium tuberculosis isoniazid resistance mutations not detectable by common molecular tests
J. L. Kandler, A. Mercante, T. Dalton, M. N. Ezewudo, L. Cowan, S. P. Burns, B. Metchock, P. Cegielski, J. E. Posey
The paper identifies novel isoniazid resistance mutations in Mycobacterium tuberculosis using whole genome sequencing and functional validation, showing WGS improves detection of resistance beyond common tests.
bioRxiv · May 15, 2018Microbiology