Cancer BiologybioRxiv
Epigenomic profiling discovers trans-lineage SOX2 partnerships driving tumor heterogeneity in lung squamous cell carcinoma
T. Sato, S. Yoo, R. Kong…·H. Watanabe
This study identifies two distinct LUSC subtypes driven by Sox2 partnerships with Brn2 or p63, revealing lineage heterogeneity and potential therapeutic targets.
DOI 10.1158/0008-5472.can-19-2132