Author

P. Dalby

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:protein structure· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Zhang· 2 shared F. G. Kozielski· 1 shared J. Tang· 1 shared N. Chakroun· 1 shared N. Codina· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 6 mutual co-author links

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2 shared papersBiophysics

C. Zhang

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2 papers

Recent·Most cited

The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer

J. Tang, C. Zhang, P. Dalby, F. G. Kozielski

The paper reports the crystal structures of a humanised A33 Fab antibody variant targeting colorectal cancer, focusing on structural features of the grafted CDRs and switch linker.

bioRxiv · Jun 21, 2022 · PreprintBiophysics

Insights into the stability of a therapeutic antibody Fab fragment by molecular dynamics and its stabilization by computational design

N. Codina, C. Zhang, N. Chakroun, P. Dalby

This paper uses molecular dynamics and computational design to analyze the stability of a therapeutic antibody Fab fragment under low pH and high temperature, identifying key regions for stabilization.

bioRxiv · May 20, 2019 · PreprintBiophysics