Author

F. G. Kozielski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:protein structure· 3 Research Focus:protein structure prediction· 2 Organism:virus· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. Lou· 3 shared S. Ma· 3 shared M. W. Bowler· 2 shared N. Pinotsis· 2 shared S. Haider· 2 shared A. Andersson Rasmussen· 1 shared C. Sele· 1 shared C. Zhang· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

J. Lou

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Oligomeric state of β-coronavirus non-structural protein 10 stimulators studied by OmniSEC and Small Angle X-ray Scattering

W. Knecht, Z. Fisher, J. Lou, C. Sele, S. Ma, A. Andersson Rasmussen, N. N. Pinotsis, F. G. Kozielski

This study characterizes the oligomeric state and structure of nsp10 from SARS, MERS, and SARS-CoV-2 using biochemical and biophysical methods, revealing it is predominantly monomeric and globular.

bioRxiv · Jun 26, 2023 · PreprintBiochemistry

High-confidence placement of difficult-to-fit fragments into electron density by using anomalous signals - a case study using hits targeting SARS-CoV-2 non-structural protein 1

F. G. Kozielski, S. Ma, M. W. Bowler, V. Mykhaylyk, N. Pinotsis

This paper demonstrates a method to identify multiple binding orientations of small molecule fragments using anomalous signals from sulphur and chlorine atoms, applied to SARS-CoV-2 nsp1 fragments.

bioRxiv · Jun 16, 2023 · PreprintBiochemistry

Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16

H. Wang, S. R. A. Rizvi, D. Dong, J. Lou, Q. Wang, W. Sopipong, Y. Su, F. Najar, P. Agarwal, F. G. Kozielski, S. Haider

This study analyzes NSP10 variants in SARS-CoV-2 using genomic data and biophysical methods, finding limited functional changes and strong conservation in its interactions with NSP14 and NSP16.

bioRxiv · Dec 23, 2022 · PreprintBiophysics

The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer

J. Tang, C. Zhang, P. Dalby, F. G. Kozielski

The paper reports the crystal structures of a humanised A33 Fab antibody variant targeting colorectal cancer, focusing on structural features of the grafted CDRs and switch linker.

bioRxiv · Jun 21, 2022 · PreprintBiophysics

Two ligand-binding sites on SARS-CoV-2 non-structural protein 1 revealed by fragment-based x-ray screening

S. Ma, S. Damfo, J. Lou, N. Pinotsis, M. W. Bowler, S. Haider, F. G. Kozielski

This study identifies two ligand-binding sites on SARS-CoV-2 nsp1 using X-ray crystallography and fragment-based screening, offering a foundation for inhibitor development.

bioRxiv · Jun 12, 2022Biochemistry