Unconstrained Precision Mitochondrial Genome Editing with αDdCBEs
S. R. Castillo, B. W. Simone, K. J. Clark, P. Devaux, S. C. Ekker
This paper introduces DdCBEs with modified TALE proteins that remove the 5-T constraint, enabling efficient and specific mitochondrial base editing at previously inaccessible sites.
bioRxiv · May 13, 2024Bioengineering