Author

P. Eggan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Assay:fluorescence / live-cell microscopy· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

S. E. Gordon· 2 shared W. N. Zagotta· 2 shared E. G. Evans· 1 shared J. Petersson· 1 shared K. D. Shaffer· 1 shared M. Tessmer· 1 shared S. Stoll· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

S. E. Gordon

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2 papers

Recent·Most cited

Ligand-Coupled Conformational Changes in a Cyclic Nucleotide-Gated Ion Channel Revealed by Time-Resolved Transition Metal Ion FRET

P. Eggan, S. E. Gordon, W. N. Zagotta

This study uses time-resolved tmFRET to analyze conformational changes and energetics in the SthK C-terminal region upon cAMP and cGMP binding, revealing large structural changes with cAMP and partial agonism with cGMP.

eLife · Dec 10, 2024Peer-reviewedBiophysics

Measuring conformational equilibria in allosteric proteins with time-resolved tmFRET

W. N. Zagotta, E. G. Evans, P. Eggan, M. Tessmer, K. D. Shaffer, J. Petersson, S. Stoll, S. E. Gordon

This paper develops a fluorescence method to measure protein conformational dynamics and energetics using time-resolved tmFRET and validates it with EPR spectroscopy.

bioRxiv · Oct 9, 2023Biophysics