Ketamine decreases HPA axis reactivity to a novel stressor in male but not female mice
C. J. Johnston, P. F. Fitzgerald, J. S. Gewarges, B. O. Watson, J. L. Spencer-Segal
This study investigates whether ketamine's antidepressant effect depends on HPA axis function, finding that ketamine reduces corticosterone response to a stressor only in male mice.
bioRxiv · Jun 29, 2021 · PreprintAnimal Behavior & Cognition