Non-canonical mitochondrial STAT3 signaling mediates exercise-induced insulin secretion down-regulation
N. C. Leite, P. F. Paula, C. Lubackzeuski, P. C. Borck, J. Juan-Mateu, J. C. Souza, D. L. Eizirik, A. C. Boschero, J.-C. Jonas, E. M. Carneiro, C. C. Zoppi
This study shows that exercise reduces insulin secretion by activating the IL-6R/pS-STAT3 pathway, which modulates mitochondrial redox state.
bioRxiv · Apr 22, 2021 · PreprintCell Biology