Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs
D. R. Stroik, D. K. Ceholski, J. Mleczko, P. F. Thanel, P. A. Bidwell, J. M. Autry, R. L. Cornea, D. D. Thomas
This paper demonstrates that expressing a PLB mutant in hiPSC-CMs improves calcium cycling and synchronicity in cardiomyopathy models.
bioRxiv · Sep 8, 2019Biophysics