Author

R. L. Cornea

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 8 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Assay:fluorescence / live-cell microscopy· 3 Organism:human· 3 Approach:microscopy & imaging analysis· 3 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

D. D. Thomas· 8 shared R. T. Rebbeck· 5 shared B. Svensson· 4 shared J. A. Schwarz· 3 shared A. N. Smith· 2 shared B. C. Knollmann· 2 shared C. C. Aldrich· 2 shared D. J. Blackwell· 2 shared

Activity by Year

2019-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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8 shared papersBiophysics

D. D. Thomas

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Author profile →

9 papers

Recent·Most cited

Kinetics and Mapping of Ca-driven Calmodulin conformations on Skeletal and Cardiac Muscle Ryanodine Receptors

R. T. Rebbeck, B. Svensson, J. Zhang, D. D. Thomas, D. M. Bers, R. L. Cornea

The paper uses FRET to study CaM conformational changes on RyR in skeletal and cardiac muscle, finding CaM becomes more compact at high Ca2+ and showing isoform-specific differences.

bioRxiv · Jul 13, 2023Biophysics

Molecular Mechanism of a FRET Biosensor for the Cardiac Ryanodine Receptor Pathologically Leaky State

B. Svensson, F. R. Nitu, R. T. Rebbeck, L. M. McGurran, T. Oda, D. D. Thomas, D. M. Bers, R. L. Cornea

This paper uses FRET to study how DPc10 and CaM interact with RyR2, revealing their distinct effects on channel function and structural changes.

bioRxiv · Jul 7, 2023 · PreprintBiophysics

ent-Verticilide B1 inhibits type 2 ryanodine receptor channels and is antiarrhythmic in Casq2-/- mice

A. Gochman, T. Q. Do, K. Kim, J. A. Schwarz, M. P. Thorpe, D. J. Blackwell, A. N. Smith, W. S. Akers, R. L. Cornea, D. L. Laver, J. N. Johnston, B. C. Knollmann

This paper identifies ent-verticilide B1 as an antiarrhythmic compound that inhibits RyR2 channels and reduces arrhythmias in Casq2-/- mice.

bioRxiv · Jul 3, 2023 · PreprintPharmacology & Toxicology

RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET

J. Seflova, J. A. Schwarz, A. N. Smith, B. Svensson, D. J. Blackwell, T. A. Phillips, R. Nikolaienko, E. Bovo, R. T. Rebbeck, A. V. Zima, D. D. Thomas, F. Van Petegem, B. C. Knollmann, J. N. Johnston, S. L. Robia, R. L. Cornea

The paper maps the binding site of ent-verticilide on RyR2 using FRET and computational methods, identifying two potential loci within the RyR2 structure.

bioRxiv · Jun 22, 2023 · PreprintBiophysics

FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators

O. Roopnarine, S. L. Yuen, A. R. Thompson, L. N. Roelike, R. T. Rebbeck, P. A. Bidwell, C. C. Aldrich, R. L. Cornea, D. D. Thomas

The paper uses a FRET assay to screen compounds affecting the cardiac SERCA pump, identifying activators and inhibitors with potential therapeutic applications for heart failure.

bioRxiv · Feb 22, 2023 · PreprintBiophysics

Cardiac RyR N-terminal region biosensors for FRET-based high-throughput screening

J. Zhang, S. M. W. K. Yuen, J. A. Schwarz, L. M. Treinen, C.-C. Tung, R. T. Rebbeck, K. Ro?man, B. Svensson, C. C. Aldrich, D. D. Thomas, F. Van Petegem, R. L. Cornea

This study develops FRET-based biosensors to screen for RyR modulators, identifying novel inhibitors and activators with therapeutic potential.

bioRxiv · Feb 7, 2021 · PreprintBiophysics

The transmembrane domain of DWORF activates SERCA directly; P15 and W22 residues are essential.

A. Li, D. R. Stroik, S. L. Yuen, E. Kleinboehl, R. L. Cornea, D. D. Thomas

This study identifies key residues in DWORF that activate SERCA2a by displacing PLB, using FRET biosensors and mutagenesis.

bioRxiv · Sep 18, 2020 · PreprintBiophysics

Structural Basis for Allosteric Control of the SERCA-Phospholamban Membrane Complex by Ca2+ and cAMP-dependent Phosphorylation

D. K. Weber, M. S. Hernandez, V. U. Reddy, S. Wang, E. K. Larsen, G. Tata, M. Gustavsson, R. L. Cornea, D. D. Thomas, A. De Simone, G. Veglia

This study reveals how phosphorylation and Ca2+ modulate the SERCA-PLN complex through structural changes that enhance Ca2+ transport.

bioRxiv · Aug 28, 2020 · PreprintBiophysics

Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs

D. R. Stroik, D. K. Ceholski, J. Mleczko, P. F. Thanel, P. A. Bidwell, J. M. Autry, R. L. Cornea, D. D. Thomas

This paper demonstrates that expressing a PLB mutant in hiPSC-CMs improves calcium cycling and synchronicity in cardiomyopathy models.

bioRxiv · Sep 8, 2019Biophysics