The veterinary anti-parasitic selamectin is a novel inhibitor of the mycobacterial DprE1 enzyme
J. M. Ezquerra-Aznarez, G. Degiacomi, H. Gasparovic, G. Stelitano, J. C. Sammartino, J. Kordulakova, P. Governa, F. Manetti, M. R. Pasca, L. R. Chiarelli, S. Ramon-Garcia
This study identifies selamectin as an inhibitor of the mycobacterial DprE1 enzyme, showing susceptibility in mutants and docking predictions, but with conflicting results in phenotypic assays and metabolic labeling.
bioRxiv · Dec 4, 2021 · PreprintMicrobiology