P. Guler

High defense system expression broadens protection range at the cost of increased autoimmunity

This study shows that increasing defense system expression in bacteria broadens protection against phages but increases autoimmunity, revealing a tradeoff in defense system regulation.

Arbitrium communication controls phage life-cycle through modulation of a bacterial anti-phage defense system

This study shows how phage phi3T uses the arbitrium system to modulate the MazEF toxin-antitoxin system, controlling the lysis/lysogeny decision in bacteria.

Dormant phages communicate to control exit from lysogeny

This study shows that phages use the arbitrium signaling system to regulate both entry into and exit from lysogeny, reducing induction rates when surrounded by other lysogens.