Endoplasmic reticulum stress delays choroid development in the HCAR1 knock-out mouse
M. Modaresinejad, X. Yang, M. A. Mohammad Nezhady, T. Zhu, E. Bajon, X. Hou, H. Tahiri, P. Hardy, J. C. Rivera, P. Lachapelle, S. Chemtob
This study shows that HCAR1 deficiency in RPE cells causes ER stress and impaired choroidal development, which is reversible with ISRIB treatment.
bioRxiv · Jan 12, 2024Cell Biology