Author

P. Lagüe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Organism:human· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

A. K. Dube· 1 shared A. Pageau· 1 shared C. R. Landry· 1 shared F. D. Rouleau· 1 shared I. Gagnon-Arsenault· 1 shared P. C. Despres· 1 shared S. Dibyachintan· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. K. Dube

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1 paper

Recent·Most cited

Deep mutational scanning of Pneumocystis jirovecii dihydrofolate reductase reveals allosteric mechanism of resistance to an antifolate

F. D. Rouleau, A. K. Dube, I. Gagnon-Arsenault, S. Dibyachintan, A. Pageau, P. C. Despres, P. Lagüe, C. R. Landry

The paper identifies 355 resistance mutations in P. jirovecii DHFR to methotrexate using deep mutational scanning, revealing an allosteric mechanism at position F199.

bioRxiv · Sep 27, 2023 · PreprintBiochemistry