Author

P. C. Despres

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:protein folding & dynamics· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:fungi (other)· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. K. Dube· 4 shared C. R. Landry· 4 shared I. Gagnon-Arsenault· 2 shared A. F. C. Caballero· 1 shared A. F. Cisneros Caballero· 1 shared A. Pageau· 1 shared C. Gagne-Thivierge· 1 shared E. M. Alexander· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersEvolutionary Biology

A. K. Dube

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4 papers

Recent·Most cited

Compensatory mutations potentiate constructive neutral evolution by gene duplication

P. C. Despres, A. K. Dube, J. Grenier, M.-E. Picard, R. Shi, C. R. Landry

The paper duplicates and evolves an homodimeric enzyme to show that compensatory mutations can lead to functional heteromers through subfunctionalization.

bioRxiv · Feb 12, 2024Evolutionary Biology

Deep mutational scanning of Pneumocystis jirovecii dihydrofolate reductase reveals allosteric mechanism of resistance to an antifolate

F. D. Rouleau, A. K. Dube, I. Gagnon-Arsenault, S. Dibyachintan, A. Pageau, P. C. Despres, P. Lagüe, C. R. Landry

The paper identifies 355 resistance mutations in P. jirovecii DHFR to methotrexate using deep mutational scanning, revealing an allosteric mechanism at position F199.

bioRxiv · Sep 27, 2023 · PreprintBiochemistry

Epistasis between promoter activity and coding mutations shapes gene evolvability

A. F. C. Caballero, I. Gagnon-Arsenault, A. K. Dube, P. C. Despres, P. Kumar, K. Lafontaine, J. N. Pelletier, C. R. Landry

The paper shows that expression level masks the effects of coding mutations, demonstrating that expression level dictates their fitness impact.

bioRxiv · Jun 7, 2022Evolutionary Biology

Asymmetrical dose-responses shape the evolutionary trade-off between antifungal resistance and nutrient use

P. C. Despres, A. F. Cisneros Caballero, E. M. Alexander, R. Sonigara, C. Gagne-Thivierge, A. K. Dube, C. R. Landry

The paper measures amino acid substitutions in yeast Fcy1 to show a trade-off between 5-FC resistance and enzyme function, with similar patterns in Cryptococcus neoformans.

bioRxiv · Nov 29, 2021Evolutionary Biology