Author

S. Dibyachintan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. K. Dube· 2 shared A. Banerjee· 1 shared A. Datey· 1 shared A. Pageau· 1 shared A. R. Sinha· 1 shared C. Landry· 1 shared C. R. Landry· 1 shared D. Bradley· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersEvolutionary Biology

A. K. Dube

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Author profile →

3 papers

Recent·Most cited

Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network

S. Dibyachintan, A. K. Dube, D. Bradley, P. Lemieux, U. Dionne, C. Landry

The paper shows that mutations in protein binding domains, combined with regulatory divergence, determine the fate of gene duplicates in a protein interaction network.

bioRxiv · Feb 23, 2024Evolutionary Biology

Deep mutational scanning of Pneumocystis jirovecii dihydrofolate reductase reveals allosteric mechanism of resistance to an antifolate

F. D. Rouleau, A. K. Dube, I. Gagnon-Arsenault, S. Dibyachintan, A. Pageau, P. C. Despres, P. Lagüe, C. R. Landry

The paper identifies 355 resistance mutations in P. jirovecii DHFR to methotrexate using deep mutational scanning, revealing an allosteric mechanism at position F199.

bioRxiv · Sep 27, 2023 · PreprintBiochemistry

A novel innate pathogen sensing strategy involving ubiquitination of bacterial surface proteins

S. Apte, S. Bhutda, S. Ghosh, K. Sharma, O. Sahay, J. Rakshit, A. R. Sinha, S. Dibyachintan, S. Roy, A. Datey, S. Santra, J. Joseph, S. Sasidharan, S. Hammerschmidt, D. Chakravortty, , A. Banerjee

The paper identifies a novel innate pathogen sensing strategy through ubiquitination of bacterial surface proteins, revealing a conserved mechanism for pathogen detection and clearance.

bioRxiv · Oct 20, 2021 · PreprintMicrobiology