SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis
This study shows that SMCR8 regulates MTORC1 and AKT signaling, affecting lysosome biogenesis and tissue homeostasis, with loss of SMCR8 causing splenomegaly and autoimmune-like phenotypes.
bioRxiv · Dec 3, 2018Cell Biology