Biochemical and Structural Characterization of Fapy·dG Replication by Human DNA Polymerase β
S. Gao, P. N. Oden, B. J. Ryan, H. Yang, B. D. Freudenthal, M. M. Greenberg
This study investigates how human DNA polymerase β processes the mutagenic lesion Fapy*dG during DNA replication, showing inefficient bypass and incorporation, suggesting mutagenicity arises from bypass rather than lesion incorporation.
bioRxiv · Jan 15, 2024Biochemistry