Author

B. J. Ryan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. D. Freudenthal· 2 shared A. Koulman· 1 shared B. Jenkins· 1 shared B. Vallin· 1 shared C. N. Krute· 1 shared C. Webber· 1 shared D. K. Johnson· 1 shared E. D. Mock· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

B. D. Freudenthal

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pathological levels of α-synuclein increase basal mitophagy in Parkinson's dopamine neurons

E. D. Mock, B. Vallin, W. McGuinness, M. C. Caiazza, M. Lavelle, B. Jenkins, M. Rokicki, A. Koulman, J. Monzon Sandoval, C. Webber, B. J. Ryan, R. Wade-Martins

This study shows that elevated α-synuclein increases basal mitophagy in Parkinson's dopamine neurons, leading to mitochondrial dysfunction and neuronal activity deficits, which can be reversed by DRP1 inhibition.

bioRxiv · Nov 2, 2026 · PreprintCell Biology

Molecular basis for the activation of the Fatty Acid Kinase complex of Staphylococcus aureus

M. J. Myers, Z. Xu, B. J. Ryan, Z. R. DeMars, M. J. Ridder, D. K. Johnson, C. N. Krute, T. S. Flynn, M. M. Kashipathy, K. P. Battaile, N. J. Schnicker, S. Lovell, B. D. Freudenthal, J. L. Bose

This study investigates the structure and function of the Fatty Acid Kinase complex in Staphylococcus aureus using modeling, biochemical, and cell-based approaches, revealing key residues and interactions essential for its activity.

bioRxiv · Mar 19, 2024 · PreprintMicrobiology

Biochemical and Structural Characterization of Fapy·dG Replication by Human DNA Polymerase β

S. Gao, P. N. Oden, B. J. Ryan, H. Yang, B. D. Freudenthal, M. M. Greenberg

This study investigates how human DNA polymerase β processes the mutagenic lesion Fapy*dG during DNA replication, showing inefficient bypass and incorporation, suggesting mutagenicity arises from bypass rather than lesion incorporation.

bioRxiv · Jan 15, 2024Biochemistry