Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline
J. E. Choby, T. Ozturk, C. N. Abbott, C. Nnabuife, J. M. Colquhoun, S. W. Satola, P. N. Rather, T. Palzkill, D. S. Weiss
The paper shows how bacteria use copy number flexibility of ESBLs to develop heteroresistance to new antibiotics like cefiderocol, threatening beta-lactam effectiveness.
bioRxiv · Jun 7, 2022Microbiology