DNMT3A harboring leukemia-associated mutations directs sensitivity to DNA damage at replication forks
K. Venugopal, P. Nowialis, Y. Feng, D. E. Shabashvili, C. M. Berntsen, K. I. Krajcik, C. Taragjini, Z. Zaroogian, H. L. Casellas-Roman, L. M. Posada, C. Gunaratne, J. Li, D. Dupere-Richer, R. L. Bennett, S. Pondugula, , O. A. Guryanova
This study shows that DNMT3A mutations impair replication fork recovery, leading to DNA damage and sensitivity to nucleoside analogs like cytarabine.
bioRxiv · May 28, 2021Cancer Biology