Author

O. A. Guryanova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Riva· 2 shared B. K. Law· 2 shared C. Gunaratne· 2 shared C. M. Berntsen· 2 shared D. E. Shabashvili· 2 shared K. I. Krajcik· 2 shared K. Venugopal· 2 shared Y. Feng· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

A. Riva

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Author profile →

3 papers

Recent·Most cited

DR5 disulfide bonding as a sensor and effector of protein folding stress

M. E. Law, Z. M. Dulloo, S. R. Eggleston, G. P. Takacs, G. M. Alexandrow, M. Wang, H. Su, B. A. Forsyth, C.-W. Chiang, A. Sharma, S. R. R. Kanumuri, O. A. Guryanova, J. K. Harrison, B. Tirosh, R. K. Castellano, B. K. Law

This study shows that disrupting DR5 disulfide bonds activates pro-apoptotic signaling and reveals DR5 disulfide bonding as a sensor and effector of ER stress in cancer cells.

bioRxiv · Mar 4, 2024 · PreprintCancer Biology

Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer

Y. Feng, R. C. Newsome, T. Robinson, R. L. Bowman, A. N. Zuniga, K. N. Hall, C. M. Berntsen, D. E. Shabashvili, K. I. Krajcik, C. Gunaratne, Z. J. Zaroogian, K. Venugopal, H. L. Casellas Roman, R. L. Levine, W. K. Chatila, , O. A. Guryanova

This study shows that hematopoietic Dnmt3a haploinsufficiency worsens colitis-associated colon cancer by promoting angiogenesis, which can be targeted with axitinib.

bioRxiv · Dec 30, 2022 · PreprintCancer Biology

DNMT3A harboring leukemia-associated mutations directs sensitivity to DNA damage at replication forks

K. Venugopal, P. Nowialis, Y. Feng, D. E. Shabashvili, C. M. Berntsen, K. I. Krajcik, C. Taragjini, Z. Zaroogian, H. L. Casellas-Roman, L. M. Posada, C. Gunaratne, J. Li, D. Dupere-Richer, R. L. Bennett, S. Pondugula, , O. A. Guryanova

This study shows that DNMT3A mutations impair replication fork recovery, leading to DNA damage and sensitivity to nucleoside analogs like cytarabine.

bioRxiv · May 28, 2021Cancer Biology