Author

P. R. Wills

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Biochemistry· 1

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Research Focus:software / tool· 1 Organism:virus· 1

Frequent Co-Authors

c. W. carter· 3 shared J. Douglas· 2 shared G. Q. Tang· 1 shared L. Betts· 1 shared R. Bouckaert· 1 shared S. K. Patra· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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3 shared papersEvolutionary Biology

c. W. carter

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3 papers

Recent·Most cited

Genomic database furnishes a spontaneous example of a functional Class II glycyl-tRNA synthetase urzyme

S. K. Patra, J. Douglas, P. R. Wills, R. Bouckaert, L. Betts, G. Q. Tang, c. W. carter

The paper identifies a functional urzyme, GlyCA, from an arctic fox genome that exhibits enhanced catalytic activity compared to known urzymes, supporting the idea that urzymes represent ancestral catalytic activities in genetic coding.

bioRxiv · Jan 11, 2024 · PreprintEvolutionary Biology

HetMM: A Michaelis-Menten model for non-homogeneous enzyme mixtures

J. Douglas, C. W. Carter, P. R. Wills

HetMM introduces a kinetic model to analyze enzyme mixtures with heterogeneous catalytic activities, showing it outperforms the standard Michaelis-Menten model in both homogeneous and heterogeneous systems.

bioRxiv · Oct 10, 2023Biochemistry

Interdependence, Reflexivity, Fidelity, Impedance Matching, And The Evolution Of Genetic Coding

C. W. Carter, P. R. Wills

This paper argues that genetic coding emerged from a peptide*RNA partnership without requiring an RNA world, emphasizing interdependence, reflexivity, and error rate compatibility in aaRS and tRNA systems.

bioRxiv · May 17, 2017Evolutionary Biology