High-throughput phenotypic screen for genetic modifiers in patient-derived OPA1 mutant fibroblasts identifies PGS1 as a functional suppressor of mitochondrial fragmentation
E. Cretin, P. Thomas, E. Vimont, T. Tatsuta, T. Langer, P. Yu-Wai-Man, P. Reynier, T. Wai
This study identifies PGS1 as a genetic modifier that suppresses mitochondrial fragmentation in OPA1 mutant fibroblasts through lipid metabolism modulation.
bioRxiv · Jan 14, 2021 · PreprintCell Biology