T. Tatsuta

Characterization of Tgl2, a putative lipase in yeast mitochondria

This study characterizes Tgl2, a putative TAG lipase in yeast mitochondria, showing its dimerization, catalytic residues, and role in mitochondrial lipid homeostasis.

De novo serine biosynthesis is protective in mitochondrial disease

This study shows that de novo serine biosynthesis protects against mitochondrial disease by maintaining metabolic homeostasis, redox balance, and lipid homeostasis in skeletal muscle.

High-throughput phenotypic screen for genetic modifiers in patient-derived OPA1 mutant fibroblasts identifies PGS1 as a functional suppressor of mitochondrial fragmentation

This study identifies PGS1 as a genetic modifier that suppresses mitochondrial fragmentation in OPA1 mutant fibroblasts through lipid metabolism modulation.

Disturbed intramitochondrial phosphatidic acid transport impairs cellular stress signaling

This study shows that impaired phosphatidic acid transport into mitochondria disrupts ER membrane homeostasis and impairs glycolytic growth and stress signaling.

A nutritional memory impairs survival, transcriptional and metabolic response to dietary restriction in old mice

This study shows that late-life dietary restriction in mice has a survival and metabolic memory effect, reducing the benefits of switching from ad libitum to restriction.