LSD1 inhibitors induce neuronal differentiation of Merkel cell carcinoma by disrupting the LSD1-CoREST complex and activating TGFβ signaling
L. Leiendecker, P. S. Jung, T. Neumann, T. Wiesner, A. C. Obenauf
The paper identifies LSD1 inhibitors as potential therapies for Merkel cell carcinoma by showing they disrupt the LSD1-CoREST complex and activate TGFβ signaling, inducing neuronal differentiation.
EMBO Molecular Medicine · Oct 7, 2020Peer-reviewedCancer Biology