Author

T. Wiesner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. Leterrier· 2 shared A. C. Obenauf· 1 shared A. Delamare· 1 shared A. M. Fundichely· 1 shared A. Polyzos· 1 shared A. Rosowicz· 1 shared C. Bock· 1 shared C. J. Lee· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

C. Leterrier

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Author profile →

5 papers

Recent·Most cited

Spectrin condensates provide a nidus for assembling the periodic axonal structure

N. P. Boyer, R. Sharma, T. Wiesner, A. Delamare, F. Pelletier, C. Leterrier, S. Roy

The paper shows spectrin condensates facilitate the formation of the periodic axonal structure by acting as local assembly hubs that later develop into a stable lattice.

bioRxiv · Jun 5, 2024 · PreprintCell Biology

TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer

E. W. P. Wong, M. Sahin, R. Yang, U. Lee, Y. A. Zhan, R. Misra, F. Tomas, N. Alomran, A. Polyzos, C. J. Lee, T. Trieu, A. M. Fundichely, T. Wiesner, A. Rosowicz, S. Cheng, , P. Chi

The paper shows that TAD hierarchy restricts LTR activation, and its loss in cancer allows LTRs to act as alternative promoters, driving oncogene activation and transcriptional diversity.

bioRxiv · May 31, 2024 · PreprintCancer Biology

pHusion: A robust and versatile toolset for automated detection and analysis of exocytosis

E. C. O'Shaughnessy, M. Lam, S. E. Ryken, T. Wiesner, K. Lukasik, J. B. Zuchero, C. Leterrier, D. Adalsteinsson, S. L. Gupton

pHusion is a toolkit for automated exocytosis analysis, showing differences in exocytic frequency and dynamics across cell types.

bioRxiv · Jul 25, 2023Cell Biology

LSD1 inhibitors induce neuronal differentiation of Merkel cell carcinoma by disrupting the LSD1-CoREST complex and activating TGFβ signaling

L. Leiendecker, P. S. Jung, T. Neumann, T. Wiesner, A. C. Obenauf

The paper identifies LSD1 inhibitors as potential therapies for Merkel cell carcinoma by showing they disrupt the LSD1-CoREST complex and activate TGFβ signaling, inducing neuronal differentiation.

EMBO Molecular Medicine · Oct 7, 2020Peer-reviewedCancer Biology

B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma

J. Griss, W. Bauer, C. Wagner, M. Maurer-Granofszky, M. Simon, M. Chen, P. Steinberger, K. Grabmeier-Pfistershammer, F. Roka, T. Penz, C. Bock, G. Zhang, M. Herlyn, K. Glatz, H. Laubli, , S. N. Wagner

bioRxiv · Jan 10, 2019Cancer Biology