Surface topography is a context-dependent activator of TGF-β signaling in mesenchymal stem cells
S. Vermeulen, N. Roumans, F. Honig, A. Carlier, D. G. Hebels, A. Dede Eren, P. ten Dijcke, A. Vasilevich, J. de Boer
The paper shows that surface topography enhances TGF-β signaling in mesenchymal stem cells through Rho/ROCK/SRF and PKC pathways, leading to increased expression of TGF-β target genes.
bioRxiv · Jan 13, 2020Cell Biology