Bile acid excess impairs thermogenic function in brown adipose tissue
W. Zhou, P. VanDuyne, C. Zhang, R. Riessen, M. Barragan, B. M. Rowitz, M. Teran-Garcia, S. A. Boppart, S. Anakk
This study shows that bile acid overload in a mouse model impairs brown adipose tissue thermogenic function, with mitochondrial dysfunction and senescence gene induction.
bioRxiv · Nov 24, 2020 · PreprintPhysiology