S. Anakk

Liver-specific Deletion Of Small Heterodimer Partner Alters Enterohepatic Bile Acid Levels And Promotes Bile Acid-Mediated Proliferation In Male Mice.

This study shows that liver-specific Shp deletion increases bile acid levels and promotes bile acid-mediated liver proliferation in male mice.

Lipid droplet structural remodeling in adipose tissue upon caloric excess

This study investigates how excess calories affect lipid droplet structure in adipose tissue, finding that bile acids and tissue-specific factors influence droplet remodeling and adipocyte size.

Splicing Factor SRSF1 Deficiency in the Liver Triggers NASH-like Pathology via R-Loop Induced DNA Damage and Cell Death

Bile acid excess impairs thermogenic function in brown adipose tissue

This study shows that bile acid overload in a mouse model impairs brown adipose tissue thermogenic function, with mitochondrial dysfunction and senescence gene induction.

Deletion of intestinal SHP impairs short-term response to cholic acid challenge in mice.

This study shows that deleting SHP in the intestine of mice impairs their response to cholic acid, affecting bile acid levels and transporters without altering FXR mRNA.

Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females.

This study identifies sex-specific bile acid metabolism differences that protect female livers from liver cancer and suggests targeting bile acid excretion as a therapeutic strategy.

Deletion and overexpression of the scaffolding protein IQGAP1 promotes HCC

This study shows that both deletion and overexpression of IQGAP1 promote hepatocellular carcinoma (HCC) through distinct mechanisms.

Constitutive Androstane Receptor contributes towards increased drug clearance in cholestasis

The paper identifies CAR activation as a mechanism for increased drug clearance in cholestasis, showing reduced drug efficacy in cholestatic mice.

Deletion of murine IQGAP1 results in increased mTOR activation and blunted ketogenic response

This study shows that IQGAP1 deletion increases mTOR activation and reduces ketosis in mice by impairing PPAR signaling.