Modeling the effect of spatial structure on solid tumor evolution and ctDNA composition
T. Rachman, D. Bartlett, W. Laframboise, P. Wagner, R. Schwartz, O. Carja
This study models how spatially variable cell death in solid tumors affects ctDNA composition and clonal representation, showing potential biases in liquid biopsy profiles.
bioRxiv · Nov 10, 2023 · PreprintCancer Biology