O. Carja

Competition for resources can reshape the evolutionary properties of spatial structure

This study combines resource competition models with evolutionary graph theory to show that ecological competition can reverse the role of amplifier and suppressor networks for deleterious mutants.

Modeling the effect of spatial structure on solid tumor evolution and ctDNA composition

This study models how spatially variable cell death in solid tumors affects ctDNA composition and clonal representation, showing potential biases in liquid biopsy profiles.

Evolutionary graph theory on rugged fitness landscapes

The paper develops a theory to model evolutionary dynamics on rugged fitness landscapes in heterogeneous population structures and applies it to bone marrow stem cell niches.

Evolutionary graph theory beyond pairwise interactions: higher-order network motifs shape times to fixation in structured populations

This paper shows how higher-order network motifs can tune fixation times without affecting fixation probabilities in structured populations, enabling continuous control over evolutionary rates in optimization problems.

A theory of evolutionary dynamics on any complex spatial structure

The paper develops a theory of evolutionary dynamics on complex spatial structures, showing that network topology and mixing patterns influence mutation fixation probabilities and suppress selection in stem cell niches.

Spatiotemporal dissection of the cell cycle with single-cell proteogenomics

The paper maps spatiotemporal proteomic heterogeneity during the cell cycle using single-cell proteogenomics and identifies 235 cell cycle-associated proteins.

CpG-creating Mutations are Costly in Many Human Viruses

The paper examines the cost of CpG-creating mutations in various human viruses using existing genomic data and finds they are generally costly.

Evolutionary rescue through partly heritable phenotypic variability

This study develops a population-genetic model to show that partly heritable phenotypic variability can increase population persistence in changing environments, but too much heritability reduces its benefit.

The evolutionary advantage of cultural memory on heterogeneous contact networks

The paper models cultural bet-hedging in evolving populations with heterogeneous contact networks, finding that cultural memory probability and network structure influence fixation probabilities of cultural traits.