Glycosaminoglycans act as activators of peptidylarginine deiminase 4
Grzegorz P. Bereta, Ewa Bielecka, Karolina Marzec, Łukasz Pijanowski, Artur P. Biela, P. Wilk, Marta Kamińska, Jakub Nowak, Elżbieta Wątor, P. Grudnik, Dominik Kowalczyk, Joanna Kozieł, Piotr Mateusz Mydel, Marcin Poręba, Tomasz Kantyka
This study identifies glycosaminoglycans as activators of PAD4, showing they enhance Ca2+ affinity and induce NETosis, with implications for rheumatoid arthritis.
Proceedings of the National Academy of Sciences · Oct 30, 2025Peer-reviewedBiochemistry