Gas tunnel engineering of prolyl hydroxylasereprograms hypoxia signaling in cells
P. Windsor, H. Ouyang, J. A. G. da Costa, A. R. Damodaran, Y. Chen, A. Bhagi-Damodaran
This study reprograms hypoxia signaling by engineering PHD2 to enhance its catalytic efficiency, leading to reduced HIF-1 and hypoxia response transcripts under low oxygen conditions.
bioRxiv · Aug 7, 2023Biochemistry