Kingdom-specific lipid unsaturation shapes up sequence evolution in membrane arm subunits of eukaryotic respiratory complexes
Pooja Gupta, Sristi Chakroborty, Arun K. Rathod, K. Ranjith Kumar, Shreya Bhat, Suparna Ghosh, Pallavi Rao T, Kameshwari Yele, Bakthisaran Raman, Ramakrishnan Nagaraj, Moutusi Manna, Swasti Raychaudhuri
The paper investigates how lipid-protein interactions constrain sequence evolution in membrane subunits of eukaryotic respiratory complexes, finding that lipid-exposed surfaces show non-PPI disease mutations and kingdom-specific lipid unsaturation affects stability.
Nature Communications · Feb 27, 2025Peer-reviewedCell Biology