Author

Pooja Gupta

Bhabha Atomic Research CentreORCID 0000-0003-0276-3573Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:Arabidopsis· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Ananda Guha MajumdariD· 2 shared Birija Sankar PatroiD· 2 shared Arun K. RathodiD· 1 shared Avik ChakrabortyiD· 1 shared Bakthisaran Raman· 1 shared Ganesh Pai BellareiD· 1 shared K. Ranjith KumariD· 1 shared Kameshwari Yele· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

Ananda Guha MajumdarORCID

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3 papers

Recent·Most cited

Cancer BiologyThe EMBO JournalPeer-reviewedMay 13, 2026

CHK1-mediated regulation of TOP1 catalytic activity suppresses replication and transcription-associated genomic instability

Ananda Guha Majumdar, Nitish Chauhan, Pooja Gupta…·Birija Sankar Patro

This study identifies CHK1's role in phosphorylating TOP1 to regulate its catalytic cycle and prevent genomic instability in cancer.

1 citation

humanDNA methylation

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Cell BiologybioRxivPreprintDec 14, 2025

WRN helicase regulates mitophagy by resolving an intricate nexus of G-quadruplexes-R loops-ATG7 pre-mRNA maturation in cancer

Pooja Gupta, Mrityunjay Tyagi, Ananda Guha Majumdar…·Birija Sankar Patro

This paper identifies WRN's role in regulating mitophagy and autophagy in cancer by resolving G-quadruplexes and R-loops to enable proper ATG7 mRNA processing.

DOI 10.64898/2025.12.11.692796

humanDNA methylation

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Cell BiologyNature CommunicationsPeer-reviewedFeb 27, 2025

Kingdom-specific lipid unsaturation shapes up sequence evolution in membrane arm subunits of eukaryotic respiratory complexes

Pooja Gupta, Sristi Chakroborty, Arun K. Rathod…·Swasti Raychaudhuri

The paper investigates how lipid-protein interactions constrain sequence evolution in membrane subunits of eukaryotic respiratory complexes, finding that lipid-exposed surfaces show non-PPI disease mutations and kingdom-specific lipid unsaturation affects stability.

3 citations

humanArabidopsis

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